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KMID : 0356920220750060487
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Korean Journal of Anesthesiology
2022 Volume.75 No. 6 p.487 ~ p.495
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Effect of equipotent doses of propofol and sevoflurane on endoplasmic reticulum stress during breast cancer surgery
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Oh Chung-Sik
Hong Seung-Wan
Park Sa-Rah
Kim Seong-Hyop
Kwon Yu-Bi
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Abstract
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Background : Numerous studies suggest that intravenous propofol is superior to inhaled volatile anesthetic. This study compared the changes in the endoplasmic reticulum (ER) stress of cancer cells and lymphocytes after propofol- and sevoflurane-based anesthesia during breast cancer surgery.
Methods : We randomized 53 patients undergoing breast cancer surgery to propofol (n = 28) and sevoflurane (n = 25) anesthesia groups. Blood samples were obtained immediately before inducing anesthesia, and 1 and 24 h postoperatively. Human breast cancer cell lines were cultured and treated with patient plasma, and the frequency of C/EBP homologous protein (CHOP) on the cancer cell lines and lymphocytes was measured. The neutrophil-to-lymphocyte ratio in plasma was evaluated in both groups.
Results : The CHOP expression on breast cancer cell lines did not differ between the groups (P = 0.108), although it decreased significantly over time (P = 0.027). The CHOP expression on lymphocytes was comparable between the groups (P = 0.485), and was the neutrophil-to-lymphocyte ratio (P = 0.501).
Conclusions : Propofol-based anesthesia did not induce greater ER stress than sevoflurane-based anesthesia during breast cancer surgery. The ER stress of cancer cells did not differ according to the type of anesthesia during breast cancer surgery.
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KEYWORD
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Anesthesia, Apoptosis, Breast neoplasms, Endoplasmic reticulum, Propofol, Sevoflurane.
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